The vast phenotypic and genotypic variance in humans has led to a growing consensus that immunology needs to adopt a systems-based, data-heavy approach to characterizing the human immune system.
The following databases may be of particular use for the human immunology researcher.
This is an open-access, online database of publicly available antibodies against human protein targets managed by Nature. The site features user and provider data on antibody efficacy in a range of biochemical and cell biological techniques.
This is the official compendium of HLA alleles and sequences, as curated by the WHO Nomenclature Committee for Factors of the HLA System. The site also includes access to published reports documenting HLA antigens, genes, and alleles. (New and confirmatory HLA sequences are available through the IMGT/HLA database.)
The goal of the International HapMap Project (International HapMap Consortium 2005) is to map and understand the patterns of common genetic diversity in the human genome in order to accelerate the search for the genetic causes of human disease.
HIV Molecular Immunology Database
The HIV Molecular Immunology Database is an annotated, searchable collection of HIV-1 cytotoxic and helper T-cell epitopes and antibody binding sites.
Immune Epitope Database and Analysis Resource
The IEDB collates data on antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species.
The dbMHC database provides an open, publicly accessible platform for DNA and clinical data related to the human Major Histocompatibility Complex (MHC). A how-to guide to using dbMHC is available here.
The dbLRC database provides a publicly accessible platform for DNA sequences and typing reagents related to the human Leukocyte Receptor Complex (LRC).
A complete database (no longer updated) of human antibody genes.
RefDIC is an open resource compendium of quantitative mRNA/Protein profile data obtained from microarray and 2DE-gel based proteome experiments, specifically for immune cells.
ImmunoQuery is a searchable database of immunostains for the differential diagnosis of tumors.