The following list of publications on human immunology may be of particular interest to any researcher following or entering this field.
Romero P et al. The Human Vaccines Project: A roadmap for cancer vaccine development. Sci Transl Med. 2016 Apr 13;8(334):334ps9.
Scientists have been pursuing the development of cancer vaccines for 40 years, but the clinical efficacy of these vaccines remains modest. Here, Romero et al suggest that a concerted international effort is needed to study human antitumor immune responses and achieve clinically effective cancer vaccines.
Boyd SD and Crowe JE Jr. Deep sequencing and human antibody repertoire analysis. Curr Opin Immunol. 2016 Jun;40:103-9.
High-throughput DNA sequencing and improved techniques for the isolation of antigen-specific B cells and their antibody genes have allowed scientists to better understand the human antibody repertoire, resulting in improved development of therapeutic antibodies. In this article, the authors highlight recent developments in this field.
Wang CX and Cannon PM. The clinical applications of genome editing in HIV. Blood. 2016 May 26;127(21):2546-52.
The recent advancement of genome editing technologies allow for more precise genetic manipulations. Here, Wang and Cannon review recent advances on the use of these gene editing techniques in T cells and hematopoietic stem/progenitor cells for HIV therapy.
Martino D and Allen K. Meeting the challenges of measuring human immune regulation. J Immunol Methods. 2015 Sep;424:1-6.
There is a need to standardize systems-wide methods for monitoring human immune regulation to identify useful hematological and serological markers for immune health. This review outlines promising advances in systems immunology.
Kolf WC et al. Accelerating next-generation vaccine development for global disease prevention. Science. 2013 May 31;340(6136):1232910.
The translation of vaccine development from animal model to humans can be a challenge. Here, Kolf et al suggest new human immunology-based clinical research initiatives in order to improve the ability to generate of vaccines that are effective in human subjects.
Gonzalez L, Strbo N and Podack ER. Humanized mice: novel model for studying mechanisms of human immune-based therapies. Immunol Res. 2013 Dec;57(1-3):326-34.
Humanized mice are useful models to study human immunity with great control and manipulability despite its limitations. This study shows that the reconstitution of newborn immunodeficient NOD/SCID-γ(c)(-/-) mice with human fetal liver-derived hematopoietic stem cells results in the most immune-competent humanized mice that can be used for testing vaccine approaches.
Montaldo E, Del Zotto G, Della Chiesa M, et al. Human NK cell receptors/markers: A tool to analyze NK cell development, subsets and function. Cytometry A. 2013. doi: 10.1002/cyto.a.22302
Natural killer (NK) cells play an important role in host defense against tumors and infections as well as in transplant rejection and tolerance induction. This article reviews the main phenotypic features of differentiating and mature human NK cell subsets in healthy donors as well as their alterations in some pathologic conditions. A brief overview of the history behind the discovery of NK cell receptors is also provided.
Holden TM, McCoy JP and Nussenblatt R. Standardizing immunophenotyping for the Human Immunology Project. Nat Rev Immunol. 2012 Feb 17;12(3):191-200
The Human Immunology Project is a comprehensive initiative to characterize the heterogeneity of the human immune system in both healthy and diseased states. In this review, the authors outline the current standardization of flow cytometry assays used for immunophenotyping human cells and summarize the steps that are required to enable the Human Immunology Project.
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